Barlas N, Mutchnick M G, Grant G J, Trainin N
Thymus. 1983 Sep;5(5-6):433-7.
Intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) in resting peripheral blood mononuclear cells (PBM) were determined in patients with alcoholic hepatitis (AH), with compensated alcoholic cirrhosis, in alcoholic subjects without liver disease and in healthy controls. The effect of thymic humoral factor (THF), a polypeptide extract of the thymus, on T lymphocyte cAMP levels was also evaluated. Only PBM from patients with AH had significantly lower resting levels of cAMP when compared to the controls. The net increase in cAMP levels induced with THF were comparable for all patient and control groups. These findings indicate the presence of an immune dysfunction in patients with AH.
测定了酒精性肝炎（AH）患者、代偿期酒精性肝硬化患者、无肝病的酗酒者及健康对照者静息外周血单个核细胞（PBM）中3',5'-环磷酸腺苷（cAMP）的细胞内水平。还评估了胸腺体液因子（THF，一种胸腺多肽提取物）对T淋巴细胞cAMP水平的影响。与对照组相比，仅AH患者的PBM静息cAMP水平显著降低。THF诱导的cAMP水平净增加在所有患者和对照组中相当。这些发现表明AH患者存在免疫功能障碍。
