庆大霉素治疗对大鼠肾组织中腺苷酸环化酶和钠钾ATP酶活性的影响。
Effect of gentamicin treatment on adenylate cyclase and Na+, K+-ATPase activities in renal tissues of rats.
作者信息
Queener S F, Luft F C, Hamel F G
出版信息
Antimicrob Agents Chemother. 1983 Nov;24(5):815-8. doi: 10.1128/AAC.24.5.815.
Abstract
Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.
摘要
庆大霉素（20毫克/千克）对雄性大鼠进行治疗后，肾皮质质膜中的钠钾ATP酶活性降低了32%。相比之下，在庆大霉素治疗的大鼠的肾小球和质膜中，异丙肾上腺素或鸟苷酸或两者对腺苷酸环化酶的刺激作用增强了两倍之多。庆大霉素的这些作用被认为与该药物引起的肾脏磷脂代谢变化有关。
相似文献
1
Effect of gentamicin treatment on adenylate cyclase and Na+, K+-ATPase activities in renal tissues of rats.庆大霉素治疗对大鼠肾组织中腺苷酸环化酶和钠钾ATP酶活性的影响。
Antimicrob Agents Chemother. 1983 Nov;24(5):815-8. doi: 10.1128/AAC.24.5.815.
2
Isoproterenol-sensitive adenylate cyclase in glomeruli isolated from young and adult rat renal cortex.从幼年和成年大鼠肾皮质分离的肾小球中对异丙肾上腺素敏感的腺苷酸环化酶
Gen Pharmacol. 1985;16(3):205-10. doi: 10.1016/0306-3623(85)90070-9.
3
Effect of prostaglandin E2 on adenylate cyclase activity in isolated glomeruli and tubules during postnatal maturation of rat renal cortex.前列腺素E2对大鼠肾皮质生后成熟过程中分离的肾小球和肾小管腺苷酸环化酶活性的影响。
Biol Neonate. 1988;53(2):113-20. doi: 10.1159/000242770.
4
Effect of DDT on adenylate cyclase activity in rat liver cell membranes.滴滴涕对大鼠肝细胞膜中腺苷酸环化酶活性的影响。
Chem Biol Interact. 1982 Apr;39(3):369-74. doi: 10.1016/0009-2797(82)90053-9.
5
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.环磷酸腺苷 - 蛋白激酶A信号转导通路对肾皮质和髓质钠钾ATP酶活性的相反作用。
J Physiol Pharmacol. 2002 Jun;53(2):211-31.
6
Preparation of renal cortex basal-lateral and bursh border membranes. Localization of adenylate cyclase and guanylate cyclase activities.肾皮质基底外侧膜和刷状缘膜的制备。腺苷酸环化酶和鸟苷酸环化酶活性的定位。
Biochim Biophys Acta. 1977 May 2;466(3):474-87. doi: 10.1016/0005-2736(77)90340-6.
7
Changes in renal phospholipid fatty acids in diabetes mellitus: correlation with changes in adenylate cyclase activity.糖尿病患者肾磷脂脂肪酸的变化：与腺苷酸环化酶活性变化的相关性
Lipids. 1983 Oct;18(10):696-705. doi: 10.1007/BF02534536.
8
Vasoactive intestinal polypeptide regulation of rabbit renal adenylate cyclase activity in vitro.血管活性肠肽对家兔肾腺苷酸环化酶活性的体外调节
J Physiol. 1987 Jun;387:1-17. doi: 10.1113/jphysiol.1987.sp016558.
9
A simple isolation method for basal-lateral plasma membranes from rat kidney cortex.一种从大鼠肾皮质分离基底外侧质膜的简单方法。
Membr Biochem. 1981;4(1):49-61. doi: 10.3109/09687688109065422.
10
Relationships between adenylate cyclase and Na+, K(+)-ATPase in rat pancreatic islets.大鼠胰岛中腺苷酸环化酶与钠钾ATP酶之间的关系
J Biol Chem. 1990 Mar 5;265(7):3936-9.
本文引用的文献
1
Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity.氨基糖苷类抗生素对肾脏溶酶体磷脂酶A和C的抑制作用：氨基糖苷类毒性的可能机制。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1663-7. doi: 10.1073/pnas.79.5.1663.
2
Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase.
J Biol Chem. 1982 Sep 25;257(18):10751-8.
3
Renal cortex ion composition and Na-K-ATPase activity in gentamicin nephrotoxicity.
Am J Physiol. 1982 May;242(5):F477-83. doi: 10.1152/ajprenal.1982.242.5.F477.
4
A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
Anal Biochem. 1974 Apr;58(2):541-8. doi: 10.1016/0003-2697(74)90222-x.
5
Preparation and characterization of a hormone-responsive renal plasma membrane fraction.激素反应性肾质膜组分的制备与表征
J Biol Chem. 1972 Nov 10;247(21):6913-8.
6
Fatty acids as modulators of membrane functions: catecholamine-activated adenylate cyclase of the turkey erythrocyte.脂肪酸作为膜功能的调节剂：火鸡红细胞中儿茶酚胺激活的腺苷酸环化酶
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3433-7. doi: 10.1073/pnas.72.9.3433.
7
Analysis of sodium fluoride enhancement of calcitonin stimulation of renal cortical adenylate cyclase.氟化钠增强降钙素对肾皮质腺苷酸环化酶刺激作用的分析。
J Biol Chem. 1978 Dec 25;253(24):9033-40.
8
Autoradiographic localization of [3H]gentamicin in the proximal renal tubules of mice.
Antimicrob Agents Chemother. 1979 Jan;15(1):131-3. doi: 10.1128/AAC.15.1.131.
9
Gentamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats.庆大霉素肾毒性。II. 对大鼠长期给药的生理、生化及形态学影响。
Virchows Arch B Cell Pathol. 1977 Jun 24;24(2):121-38.
10
Intact vesicles of canine cardiac sarcolemma: evidence from vectorial properties of Na+, K+-ATPase.犬心肌肌膜完整囊泡：钠钾ATP酶向量特性的证据
Circ Res. 1976 Oct;39(4):586-95. doi: 10.1161/01.res.39.4.586.
Zotero 插件