从幼年和成年大鼠肾皮质分离的肾小球中对异丙肾上腺素敏感的腺苷酸环化酶
Isoproterenol-sensitive adenylate cyclase in glomeruli isolated from young and adult rat renal cortex.
作者信息
Judes C, Helwig J J, Bollack C, Mandel P
出版信息
Gen Pharmacol. 1985;16(3):205-10. doi: 10.1016/0306-3623(85)90070-9.
The stimulation of the adenylate cyclase activity of isolated rat renal glomeruli by isoproterenol decreased during kidney maturation. A potentiation of the isoproterenol response by GTP was demonstrated in young and adult animals. Both KF and GPP(NH)P enhanced the enzyme activity under basal conditions in young and adult glomeruli. GTP had no significant effect upon the basal activity of the adenylate cyclase in glomeruli of 14-day old rat kidney while it had one in 21-day old and adult kidneys.
在肾脏成熟过程中，异丙肾上腺素对离体大鼠肾小球腺苷酸环化酶活性的刺激作用减弱。在幼年和成年动物中均证实了GTP对异丙肾上腺素反应的增强作用。KF和GPP(NH)P在基础条件下均可增强幼年和成年肾小球的酶活性。GTP对14日龄大鼠肾脏肾小球腺苷酸环化酶的基础活性无显著影响，而对21日龄和成年大鼠肾脏的腺苷酸环化酶基础活性有影响。
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