Huuskonen M S, Husman K, Järvisalo J, Korhonen O, Kotimaa M, Kuusela T, Nordman H, Zitting A, Mäntyjärvi R
Br J Ind Med. 1984 Feb;41(1):77-83. doi: 10.1136/oem.41.1.77.
A total of 57 subjects who had been exposed to mould dust in the tobacco industry were studied. Their working environment showed exposure to spores of different moulds, and 29 subjects (51%) showed antibodies against one or more of the microbes. Fifteen (26%) had work related respiratory symptoms. Eight (14%) showed slight radiographic pulmonary fibrosis. Spirometry showed a tendency toward restriction and obstruction, especially in small airways. Diffusion capacity was decreased in 18% of the workers. Three clinical cases of typical allergic alveolitis were also found. All this suggests that exposure of spores of different moulds (especially Aspergillus fumigatus) in the manufacture of tobacco products may induce symptoms and signs relating to extrinsic allergic alveolitis.
共对57名在烟草行业接触过霉菌粉尘的受试者进行了研究。他们的工作环境显示接触了不同霉菌的孢子，29名受试者（51%）显示出针对一种或多种微生物的抗体。15名（26%）有与工作相关的呼吸道症状。8名（14%）显示出轻微的放射性肺纤维化。肺功能测定显示有受限和阻塞的趋势，尤其是在小气道。18%的工人弥散功能下降。还发现了3例典型变应性肺泡炎的临床病例。所有这些表明，在烟草制品制造过程中接触不同霉菌（尤其是烟曲霉）的孢子可能会引发与外源性变应性肺泡炎相关的症状和体征。
