Zitting A, Huuskonen M S, Alanko K, Mattsson T
Scand J Work Environ Health. 1978 Dec;4(4):275-83. doi: 10.5271/sjweh.2698.
Radiographic and respiratory functional findings are reported for a series of 133 Finnish patients with asbestosis. Of these patients, 65 (49%) were found to have radiographically mild diffuse pulmonary fibrosis (profusion 0/1, 1/0 or 1/1), 48 (36%) moderate fibrosis (1/2, 2/1 or 2/2) and 20 (15%) diffuse fibrosis in an advanced stage (2/3 or more). The type of fibrosis was mostly irregular (110 = 83%). Fibrosis was typically the most advanced in the lower zones of the lungs. Of the 133 patients, 88 (66%) showed pleural changes and 78 (59%) pleural calcifications. The more severe the fibrosis, as seen in the radiographs, the greater the decrease in vital capacity (VC) and expiratory volume in 1 s (FEV1.0). Transfer factor was generally impaired only in advanced cases of asbestosis (fibrosis 2/3 or more). In general, obstruction was not observed in this series. Pleural changes seemed to decrease VC and FEV1.0 when the fibrosis was mild (0/1, 1/0 or 1/1). They had no effect on diffusion capacity (TLco).
报告了133例芬兰石棉沉着病患者的影像学和呼吸功能检查结果。在这些患者中，65例（49%）影像学表现为轻度弥漫性肺纤维化（肺野分布0/1、1/0或1/1），48例（36%）为中度纤维化（1/2、2/1或2/2），20例（15%）为晚期弥漫性纤维化（2/3或更高）。纤维化类型大多为不规则型（110例 = 83%）。纤维化通常在肺下部区域最为严重。133例患者中，88例（66%）有胸膜改变，78例（59%）有胸膜钙化。影像学显示纤维化越严重，肺活量（VC）和第1秒用力呼气容积（FEV1.0）下降越明显。仅在晚期石棉沉着病病例（纤维化2/3或更高）中，肺一氧化碳弥散量通常受损。总体而言，本系列中未观察到阻塞性病变。当纤维化程度较轻（0/1、1/0或1/1）时，胸膜改变似乎会降低VC和FEV1.0。它们对弥散能力（TLco）没有影响。
