Slavnov V N, Valueva G V, Luchitskiĭ E V, Iakovlev A A
Biull Eksp Biol Med. 1983 Dec;96(12):5-7.
It has been disclosed that beta-endorphin exerts marked effect on the secretion of ACTH, prolactin, corticosterone, aldosterone and somatotrophin formation in the pituitary but does not produce any effect on blood thyrotropin. Maximal rise in the concentration of the hormones was seen at the 20th minute, despite the fact that an elevation in the content of some hormones was recorded at the 5th minute following intravenous injection of beta-endorphin. At the 60th minute after beta-endorphin injection the content of prolactin, corticosterone and aldosterone in the blood dropped to the control level, while ACTH content remained significantly higher than in intact animals. One of the possible mechanisms underlying the action of beta-endorphin on the secretion of the hormones indicated might be the changes in the ratio of brain monoamines (a decrease in dopamine).
据披露，β-内啡肽对垂体中促肾上腺皮质激素、催乳素、皮质酮、醛固酮及生长激素的分泌有显著影响，但对血液中的促甲状腺激素没有任何作用。尽管在静脉注射β-内啡肽后第5分钟就记录到一些激素含量升高，但在第20分钟时激素浓度出现最大幅度上升。在注射β-内啡肽后第60分钟，血液中催乳素、皮质酮和醛固酮的含量降至对照水平，而促肾上腺皮质激素含量仍显著高于未处理动物。β-内啡肽对上述激素分泌作用的一种可能机制可能是脑单胺比例的变化（多巴胺减少）。
