Eigel P, Tschirkov A, Satter P, Knothe H
Infection. 1978;6(1):23-8. doi: 10.1007/BF01641087.
Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surgery. To clarify the question of antibacterial activity under operative conditions with the cardiopulmonary bypass, the serum and tissue levels were determined before, during and after the surgical procedure. The effectiveness of the cephalosporins against bacteria most frequently encountered in open-heart surgery was demonstrated and substantiated by the serum and tissue concentrations. It became apparent that, in view of the favorable serum and tissue levels during and after the cardiopulmonary bypass, cefamandole should be considered the antibiotic of choice in preventing infections during open-heart surgery.
28例接受心脏直视手术的患者被分为三组，每组接受头孢菌素系列中的一种不同抗生素（头孢噻吩、头孢唑林或头孢孟多）以预防感染。所有抗生素均在手术前通过静脉输注给予2g剂量。为了阐明在体外循环手术条件下的抗菌活性问题，在手术过程的术前、术中和术后测定了血清和组织水平。血清和组织浓度证明并证实了头孢菌素对心脏直视手术中最常见细菌的有效性。显而易见，鉴于体外循环期间及之后血清和组织水平良好，头孢孟多应被视为心脏直视手术中预防感染的首选抗生素。
