Müller A, Tschahargane C, Kubli F
Dtsch Med Wochenschr. 1984 Jan 13;109(2):50-4. doi: 10.1055/s-2008-1069137.
Subcutaneous mastectomy was performed in 300 patients between 1974 and 1981 for various indications. Precancerosis or non-invasive carcinomas were established by previous biopsy in 106 patients. The comparison of pathologic anatomy data of conventional and serial assessment of specimens showed an increase of clinically occult non-invasive carcinomas from 5.4 to 18.3% and of preoperatively undiagnosed invasive carcinomas from 2.3 to 7.7% in serial assessment and unchanged indication. Whereas the therapeutic value of subcutaneous mastectomy cannot be judged with certainty due to the relatively short observation period, the diagnostic value seems, according to these findings, to be ascertained. However, a much more complex histologic assessment technique beyond the usual is required.
1974年至1981年间,因各种适应证,对300例患者实施了皮下乳房切除术。106例患者通过先前活检确诊为癌前病变或非浸润性癌。对标本进行常规和系列评估的病理解剖数据比较显示,在系列评估且适应证不变的情况下,临床隐匿性非浸润性癌从5.4%增至18.3%,术前未诊断出的浸润性癌从2.3%增至7.7%。鉴于观察期相对较短,皮下乳房切除术的治疗价值尚无法确定,但根据这些发现,其诊断价值似乎可以确定。然而,需要一种比通常情况更为复杂的组织学评估技术。