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参与病毒核糖核苷酸还原酶活性的1型和2型单纯疱疹病毒多肽的免疫学特性分析

Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity.

作者信息

Bacchetti S, Evelegh M J, Muirhead B, Sartori C S, Huszar D

出版信息

J Virol. 1984 Feb;49(2):591-3. doi: 10.1128/JVI.49.2.591-593.1984.

DOI:10.1128/JVI.49.2.591-593.1984
PMID:6319760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255503/
Abstract

Mammalian cells infected with herpes simplex virus (HSV) express a novel ribonucleotide reductase which is biochemically and immunologically distinct from the uninfected-cell enzyme. Using polyvalent rabbit antiserum raised against partially purified HSV type 2 reductase as well as monoclonal antibodies to HSV type 1 and HSV type 2 early antigens, we have been able to show that in both serotypes reductase activity is associated with phosphoproteins of molecular weights 144,000 and 38,000 encoded between map units 0.566 and 0.602 in the viral genomes. The major antigenic species (144,000) have been tentatively identified as HSV type 1 ICP6 and HSV type 2 ICP10.

摘要

感染单纯疱疹病毒（HSV）的哺乳动物细胞表达一种新型核糖核苷酸还原酶，该酶在生化和免疫方面与未感染细胞的酶不同。利用针对部分纯化的2型HSV还原酶产生的多价兔抗血清以及针对1型和2型HSV早期抗原的单克隆抗体，我们已经能够证明，在这两种血清型中，还原酶活性与病毒基因组中位于图谱单位0.566至0.602之间编码的分子量为144,000和38,000的磷蛋白相关。主要抗原种类（144,000）已初步鉴定为1型HSV的ICP6和2型HSV的ICP10。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/255503/5426e91c14fc/jvirol00137-0298-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/255503/dea2efa0bba4/jvirol00137-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/255503/5426e91c14fc/jvirol00137-0298-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/255503/dea2efa0bba4/jvirol00137-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a98/255503/5426e91c14fc/jvirol00137-0298-b.jpg

相似文献

1
Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity.参与病毒核糖核苷酸还原酶活性的1型和2型单纯疱疹病毒多肽的免疫学特性分析
J Virol. 1984 Feb;49(2):591-3. doi: 10.1128/JVI.49.2.591-593.1984.
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The ribonucleotide reductase induced by herpes simplex virus type 1 involves minimally a complex of two polypeptides (136K and 38K).单纯疱疹病毒1型诱导产生的核糖核苷酸还原酶至少涉及两种多肽（136K和38K）的复合物。
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[Characteristics and physical mapping of the gene of the herpes simplex virus that controls ribonucleotide reductase activity].[控制核糖核苷酸还原酶活性的单纯疱疹病毒基因的特征与物理图谱]
Vopr Virusol. 1984 Nov-Dec;29(6):730-6.

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Herpes simplex virus 2 (HSV-2) infected cell proteins are among the most dominant antigens of a live-attenuated HSV-2 vaccine.单纯疱疹病毒2型（HSV-2）感染细胞蛋白是减毒活HSV-2疫苗中最主要的抗原之一。
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本文引用的文献

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Regulation of ribonucleotide reductase.核糖核苷酸还原酶的调控
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Herpes simplex virus-induced ribonucleotide reductase: development of antibodies specific for the enzyme.单纯疱疹病毒诱导的核糖核苷酸还原酶：该酶特异性抗体的研发
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Organization of the herpes simplex virus type 1 transcription unit encoding two early proteins with molecular weights of 140000 and 40000.编码分子量为140000和40000的两种早期蛋白的单纯疱疹病毒1型转录单元的组织方式。
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减毒单纯疱疹病毒载体诱导人视网膜上皮细胞中白细胞介素-6需要病毒复制和核因子κB激活。
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The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth.单纯疱疹病毒2型核糖核苷酸还原酶（ICP10）大亚基的PK结构域是立即早期基因表达和病毒生长所必需的。
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Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease.用1型单纯疱疹病毒性眼病小鼠模型评估一种拟肽核糖核苷酸还原酶抑制剂。
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The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.单纯疱疹病毒1型的RR1基因在感染期间由ICP0独特地反式激活。
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Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.对羟基脲有抗性的痘苗病毒：核糖核苷酸还原酶的过量产生。
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Identification of viral polypeptides involved in pseudorabies virus ribonucleotide reductase activity.参与伪狂犬病病毒核糖核苷酸还原酶活性的病毒多肽的鉴定。
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DNA amplification and neoplastic transformation mediated by a herpes simplex DNA fragment containing cell-related sequences.由包含细胞相关序列的单纯疱疹病毒DNA片段介导的DNA扩增和肿瘤转化
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Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase.单纯疱疹病毒核糖核苷酸还原酶两个亚基的鉴定与分离
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Nature. 1983 Mar 3;302(5903):76-9. doi: 10.1038/302076a0.
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Ribonucleotide reductase induced by herpes simplex virus has a virus-specified constituent.单纯疱疹病毒诱导产生的核糖核苷酸还原酶具有病毒特异性成分。
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Detailed characterization of an apparently unspliced beta herpes simplex virus type 1 gene mapping in the interior of another.对一个明显未剪接的1型单纯疱疹病毒基因的详细特征分析，该基因定位于另一个基因内部。
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Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4.针对1型单纯疱疹病毒蛋白的单克隆抗体，包括即刻早期蛋白ICP 4。
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Detailed characterization of the mRNA mapping in the HindIII fragment K region of the herpes simplex virus type 1 genome.单纯疱疹病毒1型基因组HindIII片段K区域中mRNA图谱的详细特征分析。
J Virol. 1981 Mar;37(3):1011-27. doi: 10.1128/JVI.37.3.1011-1027.1981.