Boyer J L, Cárdenas C, Posadas C, García-Sáinz J A
Life Sci. 1983 Dec 26;33(26):2627-33. doi: 10.1016/0024-3205(83)90346-6.
Administration of purified pertussis toxin to rats induced persistent tachycardia, (observed in conscious rats but not after pithing); as little as 0.05 microgram/100 g produced a significant effect. Pertussis toxin-treatment did not affected the pressor response produced in the pithed rats by the alpha 2-adrenergic agonist methoxamine but markedly diminished the pressor effect of the alpha 2-adrenergic agonists clonidine and azepexole. A role of adenylate cyclase inhibition in the action of postsynaptic vascular alpha 2-adrenergic receptors is suggested.
给大鼠注射纯化的百日咳毒素会诱发持续性心动过速（在清醒大鼠中观察到，但在脊髓切断后未观察到）；低至0.05微克/100克就会产生显著影响。百日咳毒素处理并不影响α2-肾上腺素能激动剂甲氧明在脊髓切断大鼠中产生的升压反应，但显著减弱了α2-肾上腺素能激动剂可乐定和阿泽哌唑的升压作用。这提示腺苷酸环化酶抑制在突触后血管α2-肾上腺素能受体的作用中发挥作用。
