Sircar R, Zukin S R
Life Sci. 1983;33 Suppl 1:255-8. doi: 10.1016/0024-3205(83)90491-5.
The development of stereospecific sigma opiate/phencyclidine (PCP)-binding sites in fetal and neonatal rat brain was examined. Displaceable PCP binding was detected from day 13 of gestation. Bmax values increased to adult levels just prior to birth. Apparent KD values did not change. Stereospecific binding became detectable after day 19, concomitant with a rapid increase in Bmax. Despite the early appearance of binding, pharmacologically relevant stereospecific sigma opiate/PCP-binding sites do not become evident until shortly prior to parturition.
研究了胎鼠和新生大鼠脑中立体特异性σ阿片样物质/苯环利定（PCP）结合位点的发育情况。从妊娠第13天开始检测到可置换的PCP结合。Bmax值在出生前刚升至成年水平。表观KD值没有变化。立体特异性结合在第19天后变得可检测到，同时Bmax迅速增加。尽管结合出现得早，但直到分娩前不久，药理学上相关的立体特异性σ阿片样物质/PCP结合位点才变得明显。
