Kraft K, Lang R E, Kirilow G, Maurer J, Unger T, Ganten D
Life Sci. 1983;33 Suppl 1:491-4. doi: 10.1016/0024-3205(83)90548-9.
The influence of adrenalectomy (adx), betamethasone (BET) and 11-deoxycorticosterone (DOC) on beta-endorphin-like-immunoactivity (beta-END-LI) in plasma, anterior (AP) and neuro-intermediate lobe (N-IL) of pituitary, hypothalamus (HT) and brain stem (BS) was studied in rats. One day or three weeks after adx animals were injected i.m. for five consecutive days with 0.4mg/kg BET or 3.4mg/kg DOC. Six days after adx beta-END-LI was increased in BS and plasma after four weeks there was an elevation in plasma and AP. BET suppressed beta-END-LI in plasma of both sham-adx and adx animals six days after operation and in the N-IL after six days of adx. DOC led to an increase of beta-END-LI in HT after sham-adx and to a reduction in the N-IL after four weeks of adx. These observations demonstrate that beta-END-LI is regulated differently at its sites of synthesis in the AP, N-IL and HT.
研究了肾上腺切除术（adx）、倍他米松（BET）和11-脱氧皮质酮（DOC）对大鼠血浆、垂体前叶（AP）、神经中间叶（N-IL）、下丘脑（HT）和脑干（BS）中β-内啡肽样免疫活性（β-END-LI）的影响。肾上腺切除术后1天或3周，动物连续5天肌肉注射0.4mg/kg BET或3.4mg/kg DOC。肾上腺切除术后6天，脑干和血浆中的β-END-LI增加；4周后，血浆和垂体前叶中的β-END-LI升高。术后6天，BET抑制假手术组和肾上腺切除组动物血浆中的β-END-LI，肾上腺切除术后6天抑制神经中间叶中的β-END-LI。假手术组中，DOC导致下丘脑β-END-LI增加，肾上腺切除术后4周导致神经中间叶β-END-LI减少。这些观察结果表明，β-END-LI在垂体前叶、神经中间叶和下丘脑的合成部位受到不同的调节。
