Goedert M, Mantyh P W, Emson P C, Hunt S P
Nature. 1984;307(5951):543-6. doi: 10.1038/307543a0.
The adult corpus striatum in mammals is divided into distinct histochemical compartments. If the cat caudate nucleus is stained for acetylcholinesterase a number of macroscopically visible zones appear that have lower acetylcholinesterase activity than the surrounding tissue. These patches, called 'striosomes', correspond to regions of high [Met]-enkephalin-like immunoreactivity and dense opiate receptor binding and are related to the uneven distribution of striatal efferent neurones and cortical afferent terminations. One of the highest concentrations of neurotensin-like immunoreactivity is in the striatum and the immunoreactive material co-elutes with synthetic neurotensin on gel chromatography. Recently, we have found that neurotensin-like immunoreactivity in the cat caudate nucleus coincides with the striosomes. We have now localized neurotensin receptors in the cat caudate nucleus by autoradiography and found low density in the neurotensin-rich striosomes and a high density in the neurotensin-poor surrounding tissue.
哺乳动物的成年纹状体可分为不同的组织化学区室。如果对猫的尾状核进行乙酰胆碱酯酶染色，会出现一些肉眼可见的区域，这些区域的乙酰胆碱酯酶活性低于周围组织。这些斑块被称为“纹状体小体”，对应于高[甲硫氨酸] - 脑啡肽样免疫反应性和密集阿片受体结合的区域，并且与纹状体传出神经元和皮质传入终末的不均匀分布有关。神经降压素样免疫反应性最高的区域之一在纹状体，并且免疫反应性物质在凝胶色谱上与合成神经降压素共洗脱。最近，我们发现猫尾状核中的神经降压素样免疫反应性与纹状体小体重合。我们现在通过放射自显影术在猫尾状核中定位了神经降压素受体，发现在富含神经降压素的纹状体小体中密度低，而在缺乏神经降压素的周围组织中密度高。
