van den Berg H, Schreurs W H, Joosten G P
Int J Vitam Nutr Res. 1978;48(1):12-21.
Blood levels of vitamin B1, B2, B6, B12 and folic acid were measured in a group of 37 Dutch parturient women and their full term newborns. For the evaluation of the vitamin B1, B2 and B6 status also transketolase-, glutathion reductase- and transaminase activities with their respective activation ratios were measured. In the circulation of the newborn blood levels and enzyme activities were found 1.5-2.0 times higher compared with those of the mother. Interpretation of the data obtained from the mothers using criteria coming from a group of healthy adult blood donors, revealed a relatively high incidence of marginal vitamin status, especially for vitamins B6, B12 and folic acid. By means of the enzyme activation tests even higher percentages of cases were found within the marginal or deficient range. The actual extent of vitamin deficiency in pregnancy could not be estimated, however, secondary effects seem to be involved affecting both vitamin blood levels and enzyme activities.
对37名荷兰产妇及其足月新生儿进行了维生素B1、B2、B6、B12和叶酸的血液水平检测。为评估维生素B1、B2和B6的状态，还检测了转酮醇酶、谷胱甘肽还原酶和转氨酶的活性及其各自的激活率。在新生儿的血液循环中，发现血液水平和酶活性比母亲高1.5至2.0倍。使用来自一组健康成年献血者的标准对母亲的数据进行解读，发现边缘性维生素状态的发生率相对较高，尤其是维生素B6、B12和叶酸。通过酶激活试验，发现边缘或缺乏范围内的病例百分比甚至更高。然而，无法估计孕期维生素缺乏的实际程度，似乎有继发效应影响维生素血液水平和酶活性。
