Matsumoto M, Riker W K
Neurosci Lett. 1983 Dec 2;42(2):191-5. doi: 10.1016/0304-3940(83)90405-6.
Synaptic transmission in the bullfrog sympathetic ganglion fails progressively as Ca2+ is reduced from the normal (1.8 mM) to 0.47 mM in an NaCl Ringer. This Ca2+ dependence of synaptic transmission is shifted to the left (lower Ca2+ levels) when NaCl is replaced by NaI. Replacement of NaCl by NaI also reverses pre-existing transmission failure in low Ca2+. As reported previously by us, NaI also causes repetitive postganglionic responses to each single preganglionic stimulus. It is of interest that iodide's ability to cause repetitive postganglionic responses and to shift the Ca2+ dependence of synaptic transmission duplicate the effects of aminopyridines, notably 3,4-diaminopyridine.
在牛蛙交感神经节中，当Ca2+在NaCl林格氏液中从正常的1.8 mM逐渐降低至0.47 mM时，突触传递会逐渐失效。当用NaI替代NaCl时，这种突触传递对Ca2+的依赖性向左移（更低的Ca2+水平）。用NaI替代NaCl还能逆转先前在低Ca2+环境中已出现的传递失效。正如我们之前所报道的，NaI还会使节后神经对每个节前刺激产生重复性反应。有趣的是，碘化物引起节后神经重复性反应以及改变突触传递对Ca2+依赖性的能力，与氨基吡啶类化合物，尤其是3,4 - 二氨基吡啶的作用相同。
