Finer-Moore J, Stroud R M
Proc Natl Acad Sci U S A. 1984 Jan;81(1):155-9. doi: 10.1073/pnas.81.1.155.
Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.
对乙酰胆碱受体亚基序列疏水性的傅里叶分析揭示了两亲性二级结构区域。基于该分析和一种经验预测方法对共有二级结构进行预测,得出了一个关于离子通道如何形成及可能发挥功能的可检验假设。乙酰胆碱受体三维结构的知识与所提出模型的特征相符,并提供了一些限制条件。