Grotjan H E, Leveque N W
Proc Soc Exp Biol Med. 1984 Feb;175(2):179-84. doi: 10.3181/00379727-175-41785.
Rat anterior pituitary cell cultures were utilized to compare LH and FSH release induced by LHRH, cAMP derivatives, cGMP derivatives, the calcium ionophore A23187, and elevated K+. Of the cyclic nucleotide derivatives tested, only 8-Br-cAMP released significant quantities of both LH and FSH. A23187 and elevated K+ released significant quantities of LH and FSH but supramaximal concentrations of these stimuli liberated only approximately 50% of the gonadotropins released by LHRH. Thus, none of the secretagogues tested was as efficacious as LHRH in releasing either LH or FSH.
利用大鼠垂体前叶细胞培养物来比较促黄体激素释放激素（LHRH）、环磷酸腺苷（cAMP）衍生物、环磷酸鸟苷（cGMP）衍生物、钙离子载体A23187以及高钾诱导的促黄体生成素（LH）和促卵泡生成素（FSH）释放。在所测试的环核苷酸衍生物中，只有8-溴环磷酸腺苷（8-Br-cAMP）能释放大量的LH和FSH。A23187和高钾能释放大量的LH和FSH，但这些刺激的超最大浓度仅释放了约50%由LHRH释放的促性腺激素。因此，所测试的任何一种促分泌素在释放LH或FSH方面都不如LHRH有效。
