Dellamonica P, Bernard E, Etesse H, Brun Y
Sem Hop. 1983 Dec 1;59(44):3087-8.
Selection of rifampicin-resistant Staphylococcus aureus has been described in vitro and in vivo when this compound is given as monotherapy or orally. That this occurrence may be prevented by combination-antibiotic therapy is generally accepted. We report three cases of serious staphylococcal infection treated by a synergic association of rifampicin with either an aminoglycoside or vancomycin. Therapy failed as a result of selection of the same rifampicin-resistant Staphylococcus aureus (serotype and lysotype). These observations may be explained by insufficient diffusion or inactivation of the other antibiotic in the infection site.
当利福平作为单一疗法或口服给药时，体外和体内均已出现耐利福平金黄色葡萄球菌。联合抗生素治疗可预防这种情况的发生，这一点已得到普遍认可。我们报告了3例严重葡萄球菌感染病例，这些病例采用利福平与氨基糖苷类药物或万古霉素联合使用进行治疗。由于选择了相同的耐利福平金黄色葡萄球菌（血清型和溶菌型），治疗失败。这些观察结果可能是由于感染部位其他抗生素的扩散不足或失活所致。
