Congy F, Clavel J P, Devillechabrolle A, Gerbet D, Marescot M R, Moulias R
Sem Hop. 1983 Dec 8;59(45):3105-8.
Plasma zinc levels were measured in 95 elderly patients hospitalized in a long stay unit and in 100 healthy controls under 65 years of age. Plasma zinc concentrations were significantly lower in the elderly patients, as compared to the younger subjects (p 0.001). The correlations with serum prealbumin (p 0.05) and serum albumin (p 0.05) concentrations and the frequent association with protein-calorie malnutrition suggest that the low serum zinc levels mirror a low dietary zinc intake. Immunological tests in the elderly show moderate lymphopenia, high serum IgA and frequent depression of delayed cutaneous hypersensitivity to DNCB and PHA. We find a significant correlation between plasma zinc concentration and peripheral blood lymphocyte counts, but not the other immunological parameters. Linear discriminant analysis shows that the association of low plasma zinc values, low serum protein concentration and high serum IgG concentration implies poor prognosis.
对95名长期住院的老年患者以及100名65岁以下的健康对照者测量了血浆锌水平。与年轻受试者相比，老年患者的血浆锌浓度显著较低（p<0.001）。与血清前白蛋白（p<0.05）和血清白蛋白（p<0.05）浓度的相关性以及与蛋白质 - 热量营养不良的频繁关联表明，血清锌水平低反映了膳食锌摄入量低。老年患者的免疫测试显示中度淋巴细胞减少、血清IgA升高以及对二硝基氯苯（DNCB）和植物血凝素（PHA）的迟发性皮肤超敏反应频繁受到抑制。我们发现血浆锌浓度与外周血淋巴细胞计数之间存在显著相关性，但与其他免疫参数无关。线性判别分析表明，低血浆锌值、低血清蛋白浓度和高血清IgG浓度的关联意味着预后不良。
