• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.根据条件性标记数据估计标记基因频率和连锁不平衡。
Am J Hum Genet. 1984 Jan;36(1):177-86.
2
Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy.七种DNA探针与杜兴氏和贝克氏肌肉营养不良症的遗传连锁关系。
Hum Genet. 1985;71(1):62-74. doi: 10.1007/BF00295671.
3
Genetic linkage study between the loci for Duchenne and Becker muscular dystrophy and nine X-chromosomal DNA markers.杜兴氏和贝克氏肌营养不良症基因座与九个X染色体DNA标记之间的遗传连锁研究。
Hum Genet. 1987 Jan;75(1):32-40. doi: 10.1007/BF00273835.
4
Definitive localization of Becker muscular dystrophy in Xp by linkage to a cluster of DNA polymorphisms (DXS43 and DXS9).通过与一组DNA多态性(DXS43和DXS9)连锁,将贝克尔肌营养不良症明确定位在Xp。
Hum Genet. 1985;71(1):33-6. doi: 10.1007/BF00295664.
5
Genetic linkage relationship between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophy.杜兴氏和贝克氏肌营养不良家族中Xg血型系统与两种X染色体DNA多态性之间的遗传连锁关系。
Hum Genet. 1983;65(2):169-71. doi: 10.1007/BF00286656.
6
Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy.从X染色体特异性文库中分离检测限制性片段长度多态性的探针:对杜氏肌营养不良症诊断的潜在用途。
Hum Genet. 1985;70(2):148-56. doi: 10.1007/BF00273073.
7
Linkage analysis of a DNA polymorphism proximal to the Duchenne and Becker muscular dystrophy loci on the short arm of the X chromosome.X染色体短臂上杜兴氏和贝克氏肌营养不良症基因座附近DNA多态性的连锁分析。
J Med Genet. 1985 Jun;22(3):179-81. doi: 10.1136/jmg.22.3.179.
8
Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome.贝克肌肉萎缩症与X染色体短臂上一个多态性DNA序列之间的基因连锁。
J Med Genet. 1983 Aug;20(4):255-8. doi: 10.1136/jmg.20.4.255.
9
Linkage studies in autosomal dominant facioscapulohumeral muscular dystrophy.常染色体显性面肩肱型肌营养不良的连锁研究
J Neurol Sci. 1984 Sep;65(3):261-8. doi: 10.1016/0022-510x(84)90090-x.
10
Utility and efficiency of linked marker genes for genetic counseling. III. Proportion of informative families under linkage disequilibrium.连锁标记基因在遗传咨询中的实用性和效率。III. 连锁不平衡下信息丰富家庭的比例。
Am J Hum Genet. 1983 Jul;35(4):592-610.

引用本文的文献

1
Conditional asymmetric linkage disequilibrium (ALD): extending the biallelic r2 measure.条件非对称连锁不平衡(ALD):扩展双等位基因r2测量方法
Genetics. 2014 Sep;198(1):321-31. doi: 10.1534/genetics.114.165266. Epub 2014 Jul 14.
2
Microsatellite diversity among the primitive tribes of India.印度原始部落中的微卫星多样性。
Indian J Hum Genet. 2009 Sep;15(3):114-20. doi: 10.4103/0971-6866.60187.
3
Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.家族性银屑病中人类白细胞抗原(HLA)标记的连锁分析:强烈的不平衡效应为HLA - B/-C区域的主要决定因素提供了证据。
Am J Hum Genet. 1998 Jul;63(1):191-9. doi: 10.1086/301899.
4
Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.神经纤维瘤病1型(NF1)区域的连锁不平衡:对基因定位的影响。
Am J Hum Genet. 1993 Nov;53(5):1038-50.
5
Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus.检测与疾病位点的连锁不平衡时的设计与样本量考量
Am J Hum Genet. 1994 Sep;55(3):574-80.
6
A strategy for using multiple linked markers for genetic counseling.一种使用多个连锁标记进行遗传咨询的策略。
Am J Hum Genet. 1985 Sep;37(5):984-97.
7
The use of multiple restriction fragment length polymorphisms in prenatal risk estimation. I. X-linked diseases.多种限制性片段长度多态性在产前风险评估中的应用。I. X连锁疾病。
Am J Hum Genet. 1985 Jan;37(1):60-72.
8
Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.纤溶酶原多态性的连锁不平衡及该基因在人类6号染色体6q26 - 6q27上的定位
Am J Hum Genet. 1987 Apr;40(4):338-50.
9
Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.对北美黑人和白人家庭中与囊性纤维化基因座相关的DNA多态性单倍型的分析支持囊性纤维化基因存在多种突变。
Am J Hum Genet. 1989 Mar;44(3):307-18.
10
Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases.在遗传复杂且异质性疾病中检测与显性疾病基因的标记物关联。
Am J Hum Genet. 1989 Oct;45(4):578-85.

本文引用的文献

1
Non-random association between electromorphs and inversion chromosomes in finite populations.有限群体中电泳变体与倒位染色体之间的非随机关联。
Genet Res. 1980 Feb;35(1):65-83. doi: 10.1017/s001667230001394x.
2
Evolution of the hemoglobin S and C genes in world populations.世界人群中血红蛋白S和C基因的演变。
Science. 1980 Jul 18;209(4454):388-91. doi: 10.1126/science.7384810.
3
Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.X染色体短臂上一个克隆DNA序列与杜氏肌营养不良症的连锁关系。
Nature. 1982 Nov 4;300(5887):69-71. doi: 10.1038/300069a0.
4
Utility and efficiency of linked marker genes for genetic counseling. III. Proportion of informative families under linkage disequilibrium.连锁标记基因在遗传咨询中的实用性和效率。III. 连锁不平衡下信息丰富家庭的比例。
Am J Hum Genet. 1983 Jul;35(4):592-610.
5
Genetic diagnosis of the fetus.胎儿的基因诊断。
Nature. 1982 Mar 18;296(5854):202-3. doi: 10.1038/296202a0.
6
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.利用限制性片段长度多态性构建人类遗传连锁图谱。
Am J Hum Genet. 1980 May;32(3):314-31.
7
Population heterogeneity of the Hpa I restriction site associated with the beta globin gene: implications for prenatal diagnosis.与β珠蛋白基因相关的Hpa I限制性酶切位点的群体异质性:对产前诊断的意义。
Am J Hum Genet. 1981 Jan;33(1):25-35.
8
Estimation of linkage disequilibrium in randomly mating populations.随机交配群体中连锁不平衡的估计。
Heredity (Edinb). 1974 Oct;33(2):229-39. doi: 10.1038/hdy.1974.89.
9
Heterogeneity of DNA fragments associated with the sickle-globin gene.与镰状血红蛋白基因相关的DNA片段的异质性
J Clin Invest. 1979 Sep;64(3):751-5. doi: 10.1172/JCI109519.
10
Proportion of informative families for genetic counseling with linked marker genes.用于连锁标记基因遗传咨询的信息丰富家系比例。
Jinrui Idengaku Zasshi. 1979 Sep;24(3):131-42. doi: 10.1007/BF01888684.

根据条件性标记数据估计标记基因频率和连锁不平衡。

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

作者信息

Chakravarti A, Li C C, Buetow K H

出版信息

Am J Hum Genet. 1984 Jan;36(1):177-86.

PMID:6320641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684398/
Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

摘要

提出了一种从疾病共显性标记条件数据计算基因频率和连锁不平衡的最大似然估计的方法。使用镰状细胞贫血、杜兴氏肌营养不良症以及连锁多态性限制性内切酶切割位点的数据对该方法进行了说明。