根据条件性标记数据估计标记基因频率和连锁不平衡。
Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.
作者信息
Chakravarti A, Li C C, Buetow K H
出版信息
Am J Hum Genet. 1984 Jan;36(1):177-86.
Abstract
A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.
摘要
提出了一种从疾病共显性标记条件数据计算基因频率和连锁不平衡的最大似然估计的方法。使用镰状细胞贫血、杜兴氏肌营养不良症以及连锁多态性限制性内切酶切割位点的数据对该方法进行了说明。
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