Williams R S, Caron M G, Daniel K
Am J Physiol. 1984 Feb;246(2 Pt 1):E160-7. doi: 10.1152/ajpendo.1984.246.2.E160.
To determine the relationship between oxidative capacity and characteristics of beta-adrenergic receptors (beta AR) in skeletal muscle, selected biochemical variables were quantitated in particulate preparations from soleus and gastrocnemius muscle from rats subjected to 10 wk of treadmill running and from three control groups: free-fed, sedentary controls; food-restricted, pair-weighted controls; and animals trained by swimming. Beta AR density and isoproterenol-stimulated adenylate cyclase activity were considerably greater in the slow-twitch oxidative soleus muscle than in the mixed fiber type gastrocnemius in animals from each group (P less than 0.005). Succinic dehydrogenase (SDH) activity of gastrocnemius was increased 23-42% (P less than 0.05) in runners over each of the control groups, concommitantly with a 15-27% increase (P less than 0.05) in beta AR density (Bmax for binding of 125I-cyanopindolol). In 24 animals from all four treatment groups, there was a significant correlation between SDH activity and beta AR density (r = 0.68; P less than 0.001). We conclude that BAR density correlates positively with oxidative capacity in skeletal muscle, but further studies are required to determine the physiological importance of these differences.
为了确定骨骼肌中氧化能力与β-肾上腺素能受体（βAR）特性之间的关系，对来自比目鱼肌和腓肠肌的微粒体制剂中的选定生化变量进行了定量分析。这些制剂取自经历了10周跑步机跑步训练的大鼠，以及三个对照组：自由进食的久坐不动对照组；食物限制、配对称重对照组；以及游泳训练的动物。在每组动物中，慢肌氧化型比目鱼肌中的βAR密度和异丙肾上腺素刺激的腺苷酸环化酶活性明显高于混合纤维类型的腓肠肌（P<0.005）。与对照组相比，跑步大鼠腓肠肌中的琥珀酸脱氢酶（SDH）活性增加了23%-42%（P<0.05），同时βAR密度增加了15%-27%（P<0.05）（125I-氰基吲哚洛尔结合的Bmax）。在来自所有四个治疗组的24只动物中，SDH活性与βAR密度之间存在显著相关性（r=0.68；P<0.001）。我们得出结论，骨骼肌中的βAR密度与氧化能力呈正相关，但需要进一步研究来确定这些差异的生理重要性。
