Eserhaut Drake A, DeLeo Joseph M, Provost Jessica A, Fry Andrew C
Jayhawk Athletic Performance Laboratory-Wu Tsai Human Performance Alliance, University of Kansas, Lawrence, Kansas, USA.
Female Athlete Program-Wu Tsai Human Performance Alliance, Boston Children's Hospital, Boston, Massachusetts, USA.
Physiol Rep. 2025 Jul;13(13):e70455. doi: 10.14814/phy2.70455.
The present study compared acute testosterone (T), cortisol (C), epinephrine (EPI), norepinephrine (NE), and 22 kDa growth hormone (GH-22 kDa) responses following low-load resistance exercise with blood flow restriction (LL-BFR) and traditional high-load resistance exercise (HL-RE). Twelve resistance-trained men performed bouts of LL-BFR (30%1RM) and HL-RE (70%1RM), each consisting of four sets of bilateral seated leg extensions taken to momentary task failure with 60 s rest periods. A randomized crossover design was used with time of day matched within-subjects. Upon arrival between 1200 and 1800, 24 h dietary recalls were performed with post-exercise blood samples obtained within 60 s (IP) and 5 min post-exercise (+5 min) via intravenous cannulation. Greater total repetitions (d = 2.37, p < 0.001) and less volume-load (d = 2.86, p < 0.001) were performed during LL-BFR. No Condition × Time interaction effects were found for any hormonal analyte measured (p > 0.05). Both LL-BFR and HL-RE elevate the potent β adrenergic receptor (βAR) agonist EPI (IP: 1.29 ± 0.44 and 1.35 ± 0.60 nmol·L, respectively), and the androgenic steroid T (+5 min: 27.4 ± 12.9 and 29.0 ± 14.3 nmol·L, respectively). Thus, acute skeletal muscle βAR phosphorylation may be comparable between conditions. When lower resistance exercise intensities (e.g., 30% 1RM) are desired, athletes may perform LL-BFR in place of HL-RE and experience no statistical difference in acute endocrine responses.
本研究比较了低负荷血流限制抗阻运动（LL-BFR）和传统高负荷抗阻运动（HL-RE）后急性睾酮（T）、皮质醇（C）、肾上腺素（EPI）、去甲肾上腺素（NE）和22 kDa生长激素（GH-22 kDa）的反应。12名有抗阻训练经验的男性进行了LL-BFR（30%1RM）和HL-RE（70%1RM）训练，每组均包含四组双侧坐姿腿伸展，直至瞬间任务失败，每组间休息60秒。采用随机交叉设计，受试者内的时间匹配至同一天。在12:00至18:00到达后，进行24小时饮食回顾，并通过静脉置管在运动后60秒（IP）和运动后5分钟（+5分钟）采集运动后血样。LL-BFR期间完成的总重复次数更多（d = 2.37，p < 0.001），容量负荷更少（d = 2.86，p < 0.001）。在所测量的任何激素分析物中均未发现条件×时间交互效应（p > 0.05）。LL-BFR和HL-RE均能升高强效β肾上腺素能受体（βAR）激动剂EPI（IP时分别为1.29±0.44和1.35±0.60 nmol·L），以及雄激素类固醇T（+5分钟时分别为27.4±12.9和29.0±14.3 nmol·L）。因此，不同条件下急性骨骼肌βAR磷酸化可能相当。当需要较低的抗阻运动强度（如30% 1RM）时，运动员可以进行LL-BFR替代HL-RE，且急性内分泌反应无统计学差异。
