Murphy S
Isr J Med Sci. 1978 Jan;14(1):20-37.
L2C guinea pig leukemia is a lymphoblastic neoplasm that arose spontaneously in a nonirradiated female strain 2 guinea pig over 20 years ago. Mutation of the original tumor probably accounts for the discordant results which have been reported. The LE-L2C subline was used to develop a multimodality therapy model of acute leukemia. Syngeneic strain 2 animals challenged with 3 x 10(5) LE-L2C cells developed overt leukemia in 14 +/- 3 (SD) days. When treated with cytoreductive chemotherapy, they relapsed with either systemic or central nervous system (CNS) disease. However, CNS relapse was prevented by craniospinal irradiation, yielding a uniform pattern of relapse. Preliminary studies suggest that active immunotherapy with nonspecific agents, such as BCG, or immunoreconstitution with thymosin may prolong the duration of remission and increase the percentage of long-term survivors. L2C leukemia may represent a useful animal model for structuring the principles that govern the interrelationship between chemotherapy and immunomudulation.
L2C豚鼠白血病是一种淋巴细胞性肿瘤，20多年前在一只未受辐射的2系雌性豚鼠中自发产生。原始肿瘤的突变可能是所报道的结果不一致的原因。LE-L2C亚系被用于建立急性白血病的多模式治疗模型。用3×10⁵个LE-L2C细胞攻击同基因2系动物，在14±3（标准差）天内出现明显的白血病。当接受细胞减灭性化疗时，它们会因全身性或中枢神经系统（CNS）疾病而复发。然而，通过颅脑脊髓照射可预防CNS复发，产生统一的复发模式。初步研究表明，用非特异性制剂如卡介苗进行主动免疫治疗或用胸腺素进行免疫重建可能会延长缓解期并增加长期存活者的比例。L2C白血病可能是构建化疗与免疫调节之间相互关系原则的有用动物模型。
