肾上腺皮质类固醇激素是如何导致高血压的？

"How do adrenocortical steroid hormones produce hypertension?".

作者信息

Scoggins B A, Coghlan J P, Denton D A, Mills E H, Nelson M A, Spence C D, Whitworth J A

出版信息

Clin Exp Hypertens A. 1984;6(1-2):315-28. doi: 10.3109/10641968409062568.

DOI:10.3109/10641968409062568

Abstract

ACTH dependent and independent adrenocortical steroid hypertension in experimental animals is thought to be due to the 'mineralocorticoid' and/or 'glucocorticoid' activity of the steroid/s. Studies in sheep examining ACTH and adrenocortical steroid hypertension have provided evidence for a 'hypertensinogenic' class of steroid activity. A hypothesis is proposed to explain how the 'hypertensinogenic' actions of a steroid may produce hypertension. It is suggested that effects mediated via 'mineralocorticoid' and 'glucocorticoid' receptors may modulate or amplify the 'hypertensinogenic' activity. Individual steroids may express any, all or none of these three types of steroid hormone activity.

摘要

实验动物中促肾上腺皮质激素（ACTH）依赖性和非依赖性肾上腺皮质类固醇高血压被认为是由于类固醇的“盐皮质激素”和/或“糖皮质激素”活性所致。在绵羊中研究ACTH和肾上腺皮质类固醇高血压，为一类“致高血压性”类固醇活性提供了证据。提出了一个假说来解释类固醇的“致高血压性”作用如何导致高血压。有人认为，通过“盐皮质激素”和“糖皮质激素”受体介导的效应可能调节或放大“致高血压性”活性。单个类固醇可能表现出这三种类固醇激素活性中的任何一种、全部或无。