Mills E H, Coghlan J P, Denton D A, Nelson M A, Spence C D, Whitworth J A, Scoggins B A
Clin Exp Pharmacol Physiol. 1985 Nov-Dec;12(6):587-91. doi: 10.1111/j.1440-1681.1985.tb00912.x.
The effect of treatment with 9 alpha-fluorocortisol (9 alpha FF), a steroid which causes hypertension in sheep, was examined in sheep with ACTH-induced hypertension. ACTH treatment alone increased mean arterial pressure (MAP), plasma Na concentration, water intake and urine volume and decreased plasma K concentration. 9 alpha FF treatment, for 3 days during continuing ACTH administration, did not change blood pressure but increased heart rate, water intake and urine volume and decreased urinary K excretion. As 9 alpha FF did not cause a further increment in blood pressure in sheep with ACTH-induced hypertension it is possible that both ACTH and 9 alpha FF may produce hypertension by similar mechanisms.
研究了9α-氟皮质醇（9α FF）（一种可导致绵羊高血压的类固醇）对促肾上腺皮质激素（ACTH）诱导的高血压绵羊的治疗效果。单独使用ACTH治疗可使平均动脉压（MAP）、血浆钠浓度、水摄入量和尿量增加，并使血浆钾浓度降低。在持续给予ACTH的过程中，进行为期3天的9α FF治疗，血压未发生变化，但心率、水摄入量和尿量增加，尿钾排泄减少。由于9α FF不会使ACTH诱导的高血压绵羊的血压进一步升高，因此ACTH和9α FF可能通过相似的机制产生高血压。
