Scoggins B A, Coghlan J P, Denton D A, McCarthy P J, Mason R T, Tresham J, Whitworth J A
J Endocrinol. 1985 Feb;104(2):291-4. doi: 10.1677/joe.0.1040291.
9 alpha-Fluorocortisol has been postulated to have 'hypertensinogenic' as well as 'mineralocorticoid' and 'glucocorticoid' activity. The present study examined the blood pressure and metabolic effect in sheep of the structurally related steroids 9 alpha-fluorodeoxycorticosterone (9 alpha-FDOC) and 9 alpha-fluorocorticosterone (9 alpha-FB). Infusions of these fluorinated steroids at 0.63 and 0.67 mg/day respectively for 5 days produced falls in plasma potassium, but only 9 alpha-FB increased urine volume. 9 alpha-FDOC raised mean arterial pressure by 11 mmHg and 9 alpha-FB raised it by 14 mmHg. Addition of a 9 alpha-fluoro group appears to increase both 'mineralocorticoid' and 'hypertensinogenic' steroid potencies.
据推测，9α-氟皮质醇具有“致高血压”以及“盐皮质激素”和“糖皮质激素”活性。本研究检测了结构相关类固醇9α-氟脱氧皮质酮（9α-FDOC）和9α-氟皮质酮（9α-FB）对绵羊血压和代谢的影响。分别以0.63毫克/天和0.67毫克/天的剂量输注这些氟化类固醇5天，导致血浆钾水平下降，但只有9α-FB增加了尿量。9α-FDOC使平均动脉压升高11毫米汞柱，9α-FB使平均动脉压升高14毫米汞柱。添加9α-氟基团似乎会增加“盐皮质激素”和“致高血压”类固醇的效力。
