Cohen S H, Hoeprich P D, Demling R, Gunther R, Merry J M, Franti C E, Miner D J
J Infect Dis. 1984 Feb;149(2):264-70. doi: 10.1093/infdis/149.2.264.
Following cannulation of the right external jugular vein and the efferent duct of the right caudal mediastinal lymph node (the caudal end of this node having been ligated to cut off the inflow of systemic lymph), sheep were each given one of four "cephalosporins" (cefazolin, moxalactam, cefoperazone, or ceftriaxone) as single doses injected iv over 30 min. All of the drugs appeared in the pulmonary lymph during iv infusion. Peak concentrations in the lymph were attained at 5 min postinfusion with cefazolin, cefoperazone, and ceftriaxone; the peak for moxalactam was attained at 30 min postinfusion. Cefazolin and cefoperazone penetrated better than did ceftriaxone, which penetrated better than did moxalactam. The concentrations of moxalactam, as compared with the other drugs, declined more gradually in both venous blood and pulmonary lymph. In view of the prompt entry and transit through the lungs and the high concentrations attained in the pulmonary lymph, these drugs should be effective in the treatment of pneumonias caused by susceptible bacteria.
在对右侧颈外静脉和右侧后纵隔淋巴结的输出淋巴管进行插管（该淋巴结的尾端已结扎以切断全身淋巴的流入）后，给绵羊静脉注射四种“头孢菌素”（头孢唑林、拉氧头孢、头孢哌酮或头孢曲松）中的一种，剂量为单剂量，在30分钟内静脉注射完毕。在静脉输注过程中，所有药物均出现在肺淋巴中。头孢唑林、头孢哌酮和头孢曲松在输注后5分钟达到淋巴中的峰值浓度；拉氧头孢的峰值在输注后30分钟达到。头孢唑林和头孢哌酮的穿透性比头孢曲松好，头孢曲松的穿透性比拉氧头孢好。与其他药物相比，拉氧头孢在静脉血和肺淋巴中的浓度下降更为缓慢。鉴于这些药物能迅速进入肺部并通过肺部，且在肺淋巴中达到高浓度，它们应能有效治疗由敏感细菌引起的肺炎。
