万古霉素在绵羊肺淋巴中的进入情况。
Vancomycin entry into lung lymph in sheep.
作者信息
May D G, Stratton C W, Denney W D, Watts F L, Bernard G R, Branch R A
机构信息
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
出版信息
Antimicrob Agents Chemother. 1987 Nov;31(11):1689-91. doi: 10.1128/AAC.31.11.1689.
The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.
抗生素在靶组织中的分布是治疗效果的关键因素。为了评估静脉注射万古霉素后，其在肺间质液中的可用性，我们使用了一种患有慢性肺淋巴瘘的绵羊模型，在静脉注射万古霉素（7mg/kg）后的6小时内，同时收集一系列血浆和肺淋巴样本。在从血液到淋巴的转运稍有延迟后，万古霉素完全分布到肺淋巴中，淋巴中游离药物与血浆中游离药物的比例为0.9。这表明万古霉素是治疗易感菌引起的肺部感染的极佳选择。
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