Hislop A, Reid L
J Anat. 1978 Jan;125(Pt 1):71-83.
The normal structure and pattern of branching of the pulmonary arteries of the rat have been described and quantified, using precise morphometric techniques, after injection of the pulmonary arteries with a radio-opaque medium. Rats of the same strain from three different sources have been compared, and similarities between rat and man have been assessed. In rat, as in man, the pulmonary artery accompanies the airway and branches with it and, in addition, there are extra arterial branches. Most arteries within the rat lung are muscular and have no more than two central elastic laminae. The percentage wall thickness of the muscular arteries is between 1 and 3%, similar to that found in adult human lungs. At the periphery of the arterial tree there is a mixed population of muscular, partially muscular and non-muscular arteries. The distribution by size is similar in man and rat, but there are few wholly muscular arteries within the acinar region in the rat. The similarity of the features of the pulmonary arteries of rat and man makes the rat a suitable experimental animal for study of changes in pulmonary hypertension. However, any change must be interpreted in relation to arterial structure in normal rat lungs from the same source, since some significant differences have been found between rats from different sources in respect of wall thickness and number of vessels.
在向大鼠肺动脉注射不透射线的介质后，利用精确的形态计量学技术，对大鼠肺动脉的正常结构和分支模式进行了描述和量化。比较了来自三个不同来源的同一品系大鼠，并评估了大鼠与人之间的相似性。在大鼠中，如同在人类中一样，肺动脉伴随气道并与之分支，此外，还有额外的动脉分支。大鼠肺内的大多数动脉是肌性的，且中央弹性膜不超过两层。肌性动脉的管壁厚度百分比在1%至3%之间，与成人肺中的情况相似。在动脉树的周边，存在肌性、部分肌性和非肌性动脉的混合群体。大小分布在人和大鼠中相似，但大鼠腺泡区域内几乎没有完全肌性的动脉。大鼠和人肺动脉特征的相似性使得大鼠成为研究肺动脉高压变化的合适实验动物。然而，任何变化都必须结合来自同一来源的正常大鼠肺的动脉结构来解释，因为已发现不同来源的大鼠在管壁厚度和血管数量方面存在一些显著差异。
