Brezis M, Rosen S, Silva P, Spokes K, Epstein F H
Science. 1984 Apr 6;224(4644):66-8. doi: 10.1126/science.6322305.
Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and thus increase the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited oxygen supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances thus appears to be mediated by increased oxygen demand for transport activity.
多烯类抗生素，如两性霉素和制霉菌素，会增加膜通透性，从而增加主动电解质转运过程中消耗的氧量。在离体灌注的大鼠肾脏中，多烯类抗生素对髓袢升支粗段造成了广泛损伤，该肾单位节段的氧气供应有限。如果哇巴因抑制重吸收转运，这种损伤就能得到预防。因此，在这些情况下，细胞死亡似乎是由转运活动对氧气需求的增加所介导的。
