Horschowski N, Sainty D, Dalivoust P, Tubiana N, Carcassonne Y
Sem Hop. 1984 Jan 19;60(2):77-84.
Modern physiopathological studies of the lymphoid system have enabled accurate immunological identification of the different B lymphopathies. Concurrently, the categorization of T proliferations is evolving. In addition to the morphologically well known categories of T lymphomas, three different histological entities are at present termed T lymphomas by anglo-saxon authors: lymphoma with pleiomorphic cytology, or large cell lymphoma, whose identification seems to be the most difficult; Pinkus lymphoma, with subcutaneous clinical localizations which differ from the initial sites of lymphomas, composed of lymphoid cells whose morphology is very characteristic; Lennert lymphoma, whose precise nature is still under debate, but that has been immunologically identified as a T neoplasm by some American authors. We report four observations that exemplify the complex identification of these lymphomas. One case is a Lennert lymphoma which developed into T immunoblastic lymphoma rising the problem of the relationships between these two diseases. The link between these diverse histological pictures is the T immunological identification of the proliferation for which the routine use of monoclonal antibodies should prove helpful.
现代淋巴系统生理病理学研究已能够对不同的B淋巴细胞病进行准确的免疫学鉴定。与此同时,T细胞增殖的分类也在不断发展。除了形态学上熟知的T淋巴瘤类别外,目前英美作者将三种不同的组织学实体称为T淋巴瘤:具有多形性细胞学特征的淋巴瘤,即大细胞淋巴瘤,其鉴别似乎最为困难;平卡斯淋巴瘤,临床定位于皮下,与淋巴瘤的初始部位不同,由形态非常特征性的淋巴细胞组成;勒内特淋巴瘤,其确切性质仍在争论中,但一些美国作者已通过免疫学将其鉴定为T肿瘤。我们报告了四例病例,这些病例例证了这些淋巴瘤的复杂鉴别过程。其中一例是勒内特淋巴瘤发展为T免疫母细胞淋巴瘤,引发了这两种疾病之间关系的问题。这些不同组织学表现之间的联系是增殖的T免疫学鉴定,常规使用单克隆抗体对此应会有所帮助。