Ng Cheong Ton M J, Blair R, Holmes L, Amit Z
Subst Alcohol Actions Misuse. 1983;4(4):331-6.
Animals from two different populations of Wistar rats were chronically pretreated with naltrexone for 8 days. After a 2-day rest period, animals were tested with amphetamine for locomotor activity in the open-field with or without white noise (Day 2). The rats were similarly retested on Day 7 and Day 14. New colony animals showed a significant attenuation in amphetamine locomotor activity in the absence of noise only. In contrast, chronic naltrexone significantly decreased amphetamine activity in old colony animals only under noise conditions. The possibility of an inhibitory role opiate receptors on the dopamine neuro-transmission is discussed.
来自两个不同种群的Wistar大鼠被用纳曲酮进行了为期8天的慢性预处理。在休息2天后，动物在有或无白噪声的旷场中接受苯丙胺的运动活性测试（第2天）。大鼠在第7天和第14天进行了类似的重新测试。新种群动物仅在无噪声的情况下，苯丙胺诱导的运动活性有显著减弱。相比之下，慢性纳曲酮仅在有噪声的条件下显著降低了旧种群动物的苯丙胺活性。文中讨论了阿片受体对多巴胺神经传递的抑制作用的可能性。
