Tachibana H, Meyer J S, Rose J E, Kandula P
Surg Neurol. 1984 Feb;21(2):125-31. doi: 10.1016/0090-3019(84)90329-x.
Local cerebral blood flow and local partition coefficients were measured in patients with different grades of malignant cerebral astrocytomas (n = 5) who inhaled 35% stable xenon during computed tomography scanning. Results were compared with those in age-matched normal subjects (n = 5. Mean values for local cerebral blood flow in the gray matter in patients with astrocytomas were decreased throughout the tumor mass and surrounding brain that was apparently free of tumor. Patients with highly malignant glioblastoma multiforme (astrocytoma grade IV; n = 2) showed more variable values for local cerebral blood flow and local partition coefficients compared to those with astrocytomas of lower grades (grades I-II; n = 3). Local partition coefficients in gray matter invaded by grade IV astrocytoma were significantly higher than those in gray matter invaded by grade I-III astrocytomas. Local cerebral blood flow and local partition coefficients in the brain tissue surrounding grade IV astrocytomas were reduced to a greater extent than those in more benign tumors.
在计算机断层扫描期间吸入35%稳定氙气的不同恶性程度脑星形细胞瘤患者（n = 5）中测量局部脑血流量和局部分配系数。将结果与年龄匹配的正常受试者（n = 5）的结果进行比较。星形细胞瘤患者灰质中的局部脑血流量平均值在整个肿瘤块及明显无肿瘤的周围脑组织中均降低。与低级别（I-II级；n = 3）星形细胞瘤患者相比，高度恶性多形性胶质母细胞瘤（星形细胞瘤IV级；n = 2）患者的局部脑血流量和局部分配系数值变化更大。IV级星形细胞瘤侵袭的灰质中的局部分配系数显著高于I-III级星形细胞瘤侵袭的灰质中的局部分配系数。IV级星形细胞瘤周围脑组织中的局部脑血流量和局部分配系数比更良性肿瘤中的降低程度更大。
