大细胞淋巴瘤的印戒细胞变异型

Signet-ring cell variant of large cell lymphoma.

作者信息

Dardick I, Srinivasan R, Al-Jabi M

出版信息

Ultrastruct Pathol. 1983 Sep-Oct;5(2-3):195-200. doi: 10.3109/01913128309141839.

DOI:10.3109/01913128309141839

Abstract

A diffuse, large cell lymphoma of palatine tonsil was found to contain a considerable number of enlarged tumor cells with prominent, hyaline, Russell body-type cytoplasmic inclusions displacing the nucleus peripherally and, thus, the morphologic features of signet-ring cell lymphoma. Immunoperoxidase staining revealed that the contents of the signet-ring cells were strongly positive for mu heavy chains and kappa light chains. Ultrastructurally, Russell body-type inclusions consisted of multiple, angulated, electron-dense crystalloids enclosed within expanded segments of rough endoplasmic reticulum.

摘要

腭扁桃体弥漫性大细胞淋巴瘤被发现含有大量肿大的肿瘤细胞，这些细胞具有突出的、透明的、罗素小体样的胞质内包涵体，将细胞核挤向周边，从而具有印戒细胞淋巴瘤的形态特征。免疫过氧化物酶染色显示，印戒细胞的内容物对μ重链和κ轻链呈强阳性。超微结构上，罗素小体样包涵体由多个成角的、电子致密的晶体组成，包裹在粗面内质网扩张的节段内。