躁郁症患者红细胞中锂、钠和钾的转运

Lithium, sodium and potassium transport in erythrocytes of manic-depressive patients.

作者信息

Dagher G, Gay C, Brossard M, Feray J C, Olié J P, Garay R P, Loo H, Meyer P

出版信息

Acta Psychiatr Scand. 1984 Jan;69(1):24-36. doi: 10.1111/j.1600-0447.1984.tb04513.x.

DOI:10.1111/j.1600-0447.1984.tb04513.x

Abstract

Different Li, Na and K transport pathways were assessed in erythrocytes from manic-depressive patients. No alteration in the Li-Na countertransport, Na,K cotransport or passive permeabilities was observed in either unipolar or bipolar manic-depressive patients. In addition, acute or chronic lithium treatment did not alter the maximal velocity of either the Li-Na countertransport or the Na,K cotransport. A two-fold reduction of the ouabain-sensitive Na efflux was observed among manic-depressive patients without alteration in the affinity of the Na pump for internal Na.

摘要

对躁郁症患者红细胞中的锂、钠和钾的不同转运途径进行了评估。在单相或双相躁郁症患者中，未观察到锂-钠逆向转运、钠钾协同转运或被动通透性的改变。此外，急性或慢性锂治疗并未改变锂-钠逆向转运或钠钾协同转运的最大速度。在躁郁症患者中观察到哇巴因敏感的钠外流减少了两倍，而钠泵对细胞内钠的亲和力没有改变。