Vieth W R, Chotani G
Ann N Y Acad Sci. 1983;413:114-32. doi: 10.1111/j.1749-6632.1983.tb47883.x.
Transmission at the neuromuscular junction is known to comprise the following steps: vesicular release of Ach pulses; transport across the synaptic cleft; partial hydrolysis by Ach-ase; binding to Ach receptors; ion channel opening and closure, and, thereby, alteration of sodium and potassium conductances. Combining these elements, a unified model has been constructed that is effective in describing the relation between neurotransmitter arrival at receptor sites and channel openings, leading to simple relationships for sodium and potassium conduction at the neuromuscular junction. Application of the model to mepc and epp data has been successful.
乙酰胆碱（Ach）脉冲的囊泡释放；穿过突触间隙的运输；被乙酰胆碱酯酶（Ach-ase）部分水解；与乙酰胆碱受体结合；离子通道的开放和关闭，从而改变钠和钾的电导率。综合这些要素，构建了一个统一模型，该模型有效地描述了神经递质到达受体位点与通道开放之间的关系，得出了神经肌肉接头处钠和钾传导的简单关系。该模型在微小终板电流（mepc）和终板电位（epp）数据中的应用已取得成功。
