Nadol J B, Schuknecht H F
Ann Otol Rhinol Laryngol. 1984 Jan-Feb;93(1 Pt 1):6-12. doi: 10.1177/000348948409300103.
A retrospective analysis of 29 cases of squamous cell carcinoma of the external and middle ear and 15 cases of glomus jugulare tumors of the middle ear was performed to evaluate the incidence of osteoradionecrosis of the temporal bone following surgery and/or radiotherapy. Osteoradionecrosis occurred in 42% (8/19) of cases of squamous cell carcinoma which were treated with radical mastoidectomy, lateral or subtotal temporal bone resection leaving an open cavity and followed by an average of 5,840 rad postoperatively. No osteoradionecrosis, wound breakdown or otorrhea occurred in another group of six patients who were treated by surgical exenteration, total cavity obliteration, and an average of 5,700 rad of postoperative radiotherapy. Thus, cavity obliteration significantly decreased the incidence of these complications (p less than 0.05). In contrast, in 15 patients treated by surgery and postoperative irradiation (average dose = 4,610 rad) for glomus jugulare tumors, no osteoradionecrosis occurred despite use of an open cavity technique.
对29例外耳道及中耳鳞状细胞癌和15例中耳颈静脉球瘤进行回顾性分析，以评估手术和/或放疗后颞骨放射性骨坏死的发生率。在接受根治性乳突切除术、外侧或次全颞骨切除并留开放腔隙且术后平均接受5840拉德放疗的鳞状细胞癌病例中，42%（8/19）发生了放射性骨坏死。另一组6例接受手术切除、全腔隙闭塞并术后平均接受5700拉德放疗的患者未发生放射性骨坏死、伤口裂开或耳漏。因此，腔隙闭塞显著降低了这些并发症的发生率（p<0.05）。相比之下，15例接受手术和术后放疗（平均剂量=4610拉德）治疗的颈静脉球瘤患者，尽管采用了开放腔隙技术，但未发生放射性骨坏死。
