Affolter M, Anderson A
Biochem Biophys Res Commun. 1984 Jan 30;118(2):655-62. doi: 10.1016/0006-291x(84)91353-6.
The nucleotide sequence of a cloned cDNA insert carried by pHDQ14 was determined and found to code for the 107 C-terminal amino acids of rat liver cytochrome P-450e. Comparison of the pHQ14 cDNA sequence with those of cloned cDNAs for cytochrome P-450b and of 2 P-450e-like genes revealed segmental homologies that may have resulted from gene conversion. These results suggest that gene conversion may generate sequence variants of genes for rat liver cytochrome P-450s.
测定了由pHDQ14携带的克隆cDNA插入片段的核苷酸序列，发现其编码大鼠肝细胞色素P - 450e的107个C末端氨基酸。将pHQ14 cDNA序列与细胞色素P - 450b的克隆cDNA序列以及两个P - 450e样基因的序列进行比较，发现了可能由基因转换产生的片段同源性。这些结果表明，基因转换可能会产生大鼠肝细胞色素P - 450基因的序列变体。
