Masters P S, Samuel C E
Biochem Biophys Res Commun. 1984 Feb 29;119(1):326-34. doi: 10.1016/0006-291x(84)91655-3.
The effects of a subsaturating, long treatment (24 h) dose of a highly purified cloned subspecies of human leukocyte interferon (IFN-alpha A) on vesicular stomatitis virus (VSV) primary macromolecular synthesis in tsG41-infected human amnion U cells were examined. IFN-alpha A, under these conditions, was found to inhibit primary VSV protein synthesis ten-fold while producing no detectable effect on the amount or integrity of primary viral message transcripts. There was no selective reduction by IFN-alpha A of the VSV G or M proteins.
研究了高纯度克隆的人白细胞干扰素（IFN-αA）亚种在亚饱和长时程（24小时）剂量下，对tsG41感染的人羊膜U细胞中水泡性口炎病毒（VSV）初级大分子合成的影响。在这些条件下，发现IFN-αA可将VSV初级蛋白质合成抑制10倍，而对初级病毒信使转录本的数量或完整性未产生可检测到的影响。IFN-αA对VSV的G或M蛋白没有选择性减少作用。
