氯喹 - 黑色素复合物的电子自旋共振研究。
Electron spin resonance studies of chloroquine-melanin complexes.
作者信息
Buszman E, Kopera M, Wilczok T
出版信息
Biochem Pharmacol. 1984 Jan 1;33(1):7-11. doi: 10.1016/0006-2952(84)90363-0.
Electron spin resonance (ESR) studies of chloroquine complexes with synthetic DOPA-melanin, synthetic catechol-melanin, melanin isolated from bananas and humic acid were performed. Two chloroquine concentrations (5 X 10(-5) M and 1 X 10(-3) M) were used for chloroquine-melanin complex formation. ESR studies showed differences in free radicals concentration depending on melanin origin. It was demonstrated that addition of chloroquine to melanin results in broadening of the melanin ESR signal and is accompanied by changes in the integrated intensity of the analyzed melanin samples.
对氯喹与合成的多巴黑素、合成的儿茶酚黑素、从香蕉中分离出的黑素以及腐殖酸形成的配合物进行了电子自旋共振（ESR）研究。使用两种氯喹浓度（5×10⁻⁵ M和1×10⁻³ M）来形成氯喹 - 黑素配合物。ESR研究表明，自由基浓度因黑素来源而异。结果表明，向黑素中添加氯喹会导致黑素ESR信号变宽，并伴随着所分析黑素样品积分强度的变化。
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