肾上腺皮质会影响催乳素分泌吗？对多毛症女性的评估。

Does adrenal cortex influence prolactin secretion? Evaluation in hirsute women.

作者信息

Tafaro E, Natale R, Vitale F, Giorgino R

出版信息

Boll Soc Ital Biol Sper. 1983 Dec 30;59(12):1872-6.

Abstract

To define the role of adrenal hormones on PRL secretion, we investigated 28 women by administering i.v. 0.25 mg. ACTH (h 8.00) every 45' for 135' to better evaluate any relationship between enhanced adrenal steroidogenic activity (both glycoactive and androgenic) and PRL secretion. Blood samples were drawn at 0', 45', 90', 135', and PRL, F, DHEAS, and 170HP were measured by RIA methods. A significant lowering of PRL levels and a concomitant enhancement of steroid plasma levels were found. Our data are in line with those found by some Authors who observed the lack of PRL enhancement after hypoglycemia during glucocorticoid administration and the absence of nocturnal peak of PRL in patients with Cushing's disease. However statistical evaluation (linear analysis regression) of data obtained provides further evidence for the extremely influential role played by adrenal gland hormones on PRL secretion in women.

摘要

为了确定肾上腺激素对催乳素（PRL）分泌的作用，我们对28名女性进行了研究，通过每45分钟静脉注射0.25毫克促肾上腺皮质激素（ACTH，上午8点），共注射135分钟，以更好地评估增强的肾上腺类固醇生成活性（包括糖活性和雄激素活性）与PRL分泌之间的任何关系。在0分钟、45分钟、90分钟、135分钟采集血样，并用放射免疫分析方法测定PRL、F、硫酸脱氢表雄酮（DHEAS）和17α-羟孕酮（170HP）。发现PRL水平显著降低，同时血浆类固醇水平升高。我们的数据与一些作者的发现一致，他们观察到在给予糖皮质激素期间低血糖后PRL没有升高，以及库欣病患者中PRL夜间峰值缺失。然而，对所获得数据的统计评估（线性分析回归）进一步证明了肾上腺激素对女性PRL分泌具有极其重要的影响作用。