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108CC15神经母细胞瘤X胶质瘤杂交细胞上δ-阿片受体密度的调节

The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells.

作者信息

Moses M A, Snell C R

出版信息

Br J Pharmacol. 1984 Jan;81(1):169-74. doi: 10.1111/j.1476-5381.1984.tb10757.x.

DOI:10.1111/j.1476-5381.1984.tb10757.x
PMID:6322893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1986939/
Abstract

The effect of exogenous substances on the expression of opiate receptors on 108CC15 neuroblastoma X glioma hybrid cells has been studied. Cell differentiation by culture in the presence of N6-O2-dibutyryl adenosine 3',5'-cyclic monophosphate induced a three fold increase in opiate receptor density. When the cells were grown in the presence of 10(-5) M morphine hydrochloride for up to 23 days, opiate receptor densities were reduced by only 30% when compared with matched controls. Culture in the presence of 10(-7) M D-Ala2-D-Leu5-enkephalin produced opiate receptor down regulation of 73% compared to controls after only 4 h of treatment. The down regulation process could be inhibited by continued exposure to D-Ala2 D-Leu5-enkephalin at concentrations greater than 4 nM; below this concentration down regulation was rapid and irreversible. A model to explain these observations is described.

摘要

已研究了外源性物质对108CC15神经母细胞瘤X胶质瘤杂交细胞上阿片受体表达的影响。在N6 - O2 - 二丁酰腺苷3',5' - 环磷酸存在下培养诱导细胞分化，使阿片受体密度增加了三倍。当细胞在10(-5)M盐酸吗啡存在下生长长达23天时，与配对对照相比，阿片受体密度仅降低了30%。在10(-7)M D - Ala2 - D - Leu5 - 脑啡肽存在下培养，仅处理4小时后，与对照相比阿片受体下调了73%。继续暴露于浓度大于4 nM的D - Ala2 D - Leu5 - 脑啡肽可抑制下调过程；低于此浓度时，下调迅速且不可逆。描述了一个解释这些观察结果的模型。

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本文引用的文献

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