Ratnikov V I, Nesterenko V G
Farmakol Toksikol. 1984 Jan-Feb;47(1):81-4.
Administration of methyluracil (20 mg/kg), dibasol (2 mg/kg), prodigiosan (5 micrograms/kg) and levamisole (2.5 mg/kg) to rabbits was followed by stimulation of phagocytic activity of peripheral blood neutrophils. As regards the degree of the effect, the drugs might be arranged in the following way: prodigiosan greater than levamisole greater than methyluracil greater than dibazol. The induction effects of levamisole and prodigiosan on the activity of the myeloperoxidase bactericidal system and alkaline phosphatase in leukocytes correlated with an increase in their functional activity. In contrast to the drugs indicated, the phagocytosis-stimulating action of methyluracil on peripheral blood neutrophils was not apparently mediated via the bactericidal systems studied but via other mechanisms one of which might be activation of nucleo- and proteinosynthesis. In the dose indicated dibasol did not produce any essential effect on the phagocytic response and intracellular bactericidal systems of phagocytes. All the drugs under study did not produce any effect on the neutrophil content of non-enzymatic cation proteins.
给家兔注射甲基尿嘧啶（20毫克/千克）、地巴唑（2毫克/千克）、灵菌红素（5微克/千克）和左旋咪唑（2.5毫克/千克）后，外周血中性粒细胞的吞噬活性受到刺激。就作用程度而言，这些药物的排列顺序如下：灵菌红素＞左旋咪唑＞甲基尿嘧啶＞地巴唑。左旋咪唑和灵菌红素对白细胞中髓过氧化物酶杀菌系统和碱性磷酸酶活性的诱导作用与其功能活性的增加相关。与上述药物不同，甲基尿嘧啶对外周血中性粒细胞的吞噬刺激作用显然不是通过所研究的杀菌系统介导的，而是通过其他机制，其中之一可能是核酸和蛋白质合成的激活。在所给剂量下，地巴唑对吞噬细胞的吞噬反应和细胞内杀菌系统没有产生任何显著影响。所有所研究的药物对非酶阳离子蛋白的中性粒细胞含量均无影响。
