Pruzanski W, Saito S
J Rheumatol. 1983 Oct;10(5):688-93.
Six immunomodulators were tested for the influence on phagocytosis and intracellular bactericidal activity of human polymorphonuclear cells (PMN). Frentizole, lamprene, intal and levamisole but not dapsone enhanced phagocytosis in the presence of serum. Without serum, frentizole strongly enhanced phagocytosis, whereas lamprene, levamisole and dapsone had weaker enhancing activity. Rifampin suppressed phagocytosis of Staphylococcus aureus whether the serum was present or not. The influence on phagocytosis was time and dose dependent. All drugs but dapsone markedly enhanced intracellular bactericidal activity of PMN in a dose dependent fashion. Dapsone enhanced bactericidal activity without the serum and suppressed it in its presence. It may be concluded that immunomodulators are a heterogeneous group of substances and their influence on phagocytosis and cellular bactericidal activity varies. Enhancing activity of some immunomodulators implies that they may be used in conditions with impaired phagocytosis.
测试了六种免疫调节剂对人多形核细胞（PMN）吞噬作用和细胞内杀菌活性的影响。氟苯达唑、氯法齐明、色甘酸钠和左旋咪唑（但氨苯砜除外）在有血清存在的情况下增强吞噬作用。无血清时，氟苯达唑强烈增强吞噬作用，而氯法齐明、左旋咪唑和氨苯砜的增强活性较弱。无论有无血清，利福平均抑制金黄色葡萄球菌的吞噬作用。对吞噬作用的影响具有时间和剂量依赖性。除氨苯砜外，所有药物均以剂量依赖性方式显著增强PMN的细胞内杀菌活性。氨苯砜在无血清时增强杀菌活性，而在有血清时则抑制杀菌活性。可以得出结论，免疫调节剂是一类异质性物质，它们对吞噬作用和细胞杀菌活性的影响各不相同。一些免疫调节剂的增强活性表明它们可用于吞噬作用受损的情况。
