柯萨奇B病毒特异性IgM放射免疫测定中的异型反应
Heterotypic reactions in a radioimmunoassay for coxsackie B virus specific IgM.
作者信息
Pugh S F
出版信息
J Clin Pathol. 1984 Apr;37(4):433-9. doi: 10.1136/jcp.37.4.433.
Abstract
IgM antibody capture radioimmunoassays were developed to detect coxsackie virus B1-B5 specific IgM. Specific IgM was detected in sera from all patients with coxsackie B virus infections proved by isolation; however, sera from 13/32 patients with rising neutralising antibody titres were negative in the assay. Frequent heterotypic responses were seen among the positive sera. Thirty seven patients with other enterovirus infections were also studied, and sera from 15 of these patients reacted in the assay, showing that heterotypic coxsackie B IgM responses occur not only in coxsackie B virus infections but also in other enterovirus infections.
摘要
开发了IgM抗体捕获放射免疫分析法来检测柯萨奇病毒B1 - B5特异性IgM。在所有经病毒分离证实为柯萨奇B病毒感染的患者血清中均检测到特异性IgM；然而，在32例中和抗体滴度升高的患者中，有13例患者的血清在该检测中呈阴性。在阳性血清中经常出现异型反应。还对37例其他肠道病毒感染患者进行了研究，其中15例患者的血清在该检测中出现反应，表明异型柯萨奇B IgM反应不仅发生在柯萨奇B病毒感染中，也发生在其他肠道病毒感染中。
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