Bautista A P, Solomon J B
J Leukoc Biol. 1984 Apr;35(4):415-26. doi: 10.1002/jlb.35.4.415.
Activation of alveolar, peritoneal, liver, and spleen macrophages was measured by decreased 5'-nucleotidase and elevated alkaline phosphodiesterase I activities in newborn and juvenile guinea pigs for up to 48 days after intracardiac or intranasal infection with Mycobacterium microti. Increased AP and reduced 5'-nucleotidase activity in cell lysates of macrophages appeared to be related to the carrier state during infection. Intranasal infection of 8-week-old guinea pigs with M. microti produced decreases of 5'-nucleotidase activity in alveolar macrophages during 1-8 weeks post infection and in macrophages from all four sources from 4-8 weeks.
通过测量新生和幼年豚鼠心脏内或鼻内感染微小分枝杆菌后长达48天的5'-核苷酸酶活性降低和碱性磷酸二酯酶I活性升高，来检测肺泡、腹膜、肝脏和脾脏巨噬细胞的激活情况。巨噬细胞裂解物中碱性磷酸酶增加和5'-核苷酸酶活性降低似乎与感染期间的携带状态有关。8周龄豚鼠鼻内感染微小分枝杆菌后，感染后1-8周肺泡巨噬细胞中的5'-核苷酸酶活性降低，感染后4-8周来自所有四个来源的巨噬细胞中的5'-核苷酸酶活性降低。
