Gigliotti F, Hendley J O, Morgan J, Michaels R, Dickens M, Lohr J
J Pediatr. 1984 Apr;104(4):623-6. doi: 10.1016/s0022-3476(84)80566-1.
We studied 102 children aged 1 month to 18 years in a randomized, double-blind trial designed to determine both the natural history of bacterial conjunctivitis and whether topical antibiotic therapy is beneficial. Affected eyes were treated four times a day for 7 days with drug (polymyxin-bacitracin ophthalmic ointment) or placebo. Eighty-four patients had proved bacterial conjunctivitis (Haemophilus influenzae 61, Streptococcus pneumoniae 22, both one); 66 of these received only topical therapy. By 3 to 5 days, 21 of 34 (62%) patients receiving topical antibiotic were clinically cured, whereas only nine of 32 (28%) patients given placebo were cured (P less than 0.02). By 8 to 10 days, 31 (91%) of the patients given antibiotic and 23 (72%) of the placebo group were cured (P = NS). The bacterial pathogen was eradicated by day 3 to 5 in 71% and by day 8 to 10 in 79% of patients given antibiotic, compared to 19% and 31% of the placebo group (P less than 0.001). Acute bacterial conjunctivitis is a self-limited disease, but topical antibiotic therapy with polymyxin-bacitracin shortens the duration of clinical disease and enhances eradication of the causative organism from the conjunctiva.
我们在一项随机双盲试验中研究了102名年龄在1个月至18岁之间的儿童，该试验旨在确定细菌性结膜炎的自然病程以及局部抗生素治疗是否有益。受影响的眼睛每天用药物（多粘菌素 - 杆菌肽眼膏）或安慰剂治疗4次，持续7天。84例患者确诊为细菌性结膜炎（流感嗜血杆菌61例，肺炎链球菌22例，两种细菌感染各1例）；其中66例仅接受局部治疗。到3至5天时，接受局部抗生素治疗的34例患者中有21例（62%）临床治愈，而接受安慰剂治疗的32例患者中只有9例（28%）治愈（P<0.02）。到8至10天时，接受抗生素治疗的患者中有31例（91%）治愈而安慰剂组有23例（72%）治愈（P=无统计学意义）。接受抗生素治疗的患者中，71%在3至5天时细菌病原体被根除，79%在8至10天时被根除，相比之下，安慰剂组分别为19%和31%（P<0.001）。急性细菌性结膜炎是一种自限性疾病，但多粘菌素 - 杆菌肽局部抗生素治疗可缩短临床疾病持续时间，并增强从结膜中根除致病微生物的能力。
