核心组蛋白组分和鱼精蛋白介导的DNA超螺旋化
DNA supercoiling by core histone fractions and protamine.
作者信息
Vashakidze R P, Karpenchuk K G, Undritsov I M, Naktinis V I
出版信息
Mol Biol Rep. 1984 Jan;9(4):259-62. doi: 10.1007/BF00775358.
PMID:6323967
Abstract
The nuclear extract isolated from late Drosophila melanogaster embryos has Mg2+-dependent DNA topoisomerase 1 and nuclease activities. The extract facilitates the closed circular duplex DNA supercoiling in the presence of calf histone fractions H2A, H2B, H3 and H4, and fish protamine but not HI histone.
摘要
从晚期黑腹果蝇胚胎中分离出的核提取物具有Mg2+依赖的DNA拓扑异构酶1和核酸酶活性。在存在小牛组蛋白组分H2A、H2B、H3和H4以及鱼精蛋白但不存在H1组蛋白的情况下，该提取物促进闭环双链DNA超螺旋化。
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