Bicknell R J, Ingram C D, Leng G
Neurosci Lett. 1983 Dec 30;43(2-3):227-30. doi: 10.1016/0304-3940(83)90192-1.
Previous experiments have shown that the amount of oxytocin released by electrical stimulation from an isolated rat neurointermediate lobe is about doubled in the presence of the opiate antagonist naloxone. To test whether the opiates from the intermediate lobe inhibit the release of oxytocin, we performed similar experiments on the isolated neural lobe, after almost total removal of intermediate lobe tissue. The potentiating effect of naloxone upon oxytocin release was undiminished, suggesting that the endogenous opiate responsible for inhibiting oxytocin secretion comes from the neural lobe itself.
先前的实验表明，在存在阿片类拮抗剂纳洛酮的情况下，从分离出的大鼠神经中间叶通过电刺激释放的催产素量大约会增加一倍。为了测试中间叶的阿片类物质是否抑制催产素的释放，在几乎完全去除中间叶组织后，我们对分离出的神经叶进行了类似的实验。纳洛酮对催产素释放的增强作用并未减弱，这表明负责抑制催产素分泌的内源性阿片类物质来自神经叶本身。
