Zimber A, Perk K, Hod I, Irving S, Yegana Y
Res Vet Sci. 1984 Jan;36(1):122-4.
Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.
将从由C型RNA逆转录病毒诱导的绵羊肺腺瘤病获得的切碎组织皮下接种到雄性ICR裸鼠体内，形成了一个含有由增殖上皮衬里的囊肿的移植瘤。这些囊肿显示出起源上皮肿瘤细胞的几个特征，如高糖原含量和粘蛋白分泌。观察到腺瘤性囊肿的上皮细胞向间质的微侵袭。间质组织显示有软骨岛。得出结论，绵羊病毒诱导的肺癌可以在裸鼠体内移植并生长。
